Study may lead to new strategies against sepsis
The findings, reported online January 25, 2013 in the Journal of Clinical Investigation, provide new insights into molecular details underlying sepsis and its effects on the lungs. In identifying...
View ArticleStudy finds key protein for firing up central nervous system inflammation
An international team of researchers led by scientists in The University of Texas MD Anderson Cancer Center Department of Immunology reported their results in an advance online publication in Nature...
View ArticleBlocking Tumor-Induced Inflammation Impacts Cancer Development (University...
How tumors exploit microflora and immune cells to fuel growth Mouse colorectal tumors display inflammatory infiltration by macrophages (green) and activated stromal cells (red). The question of why...
View ArticleEmber Therapeutics Announces Cell Publication of Key Data Showing TRPV4...
Small Molecule Inhibition of Key Ion Channel Could Represent a New Therapeutic Approach to Metabolic Disease; Ember Holds Exclusive Licensing Option on TRPV4 Intellectual Property BOSTON--(BUSINESS...
View ArticleClues to heart disease in unexpected places, researchers discover
The study is the first to identify the molecule, an enzyme known as GRK2 (G protein-coupled receptor kinase 2), in mitochondria. It was led by Walter J. Koch, Ph.D., Professor and Chairman of the...
View ArticleEleven Biotherapeutics Publishes Data on EBI-005, a Novel IL-1 Inhibitor...
Results in Proceedings of the National Academy of Sciences Highlight the Beneficial Effects of EBI-005 Rationally-designed to Target and Block IL-1 for Ocular Inflammation CAMBRIDGE, Mass.--(BUSINESS...
View ArticleA better bone marrow transplant: Preventing graft-versus-host disease
University of Michigan researchers have discovered that inhibiting a signaling pathway in some of the transplanted cells could prevent the most serious potential complications of the procedure, a...
View ArticleCaffeine may block inflammation linked to mild cognitive impairment
"We have discovered a novel signal that activates the brain-based inflammation associated with neurodegenerative diseases, and caffeine appears to block its activity. This discovery may eventually lead...
View ArticleUSC research on cold sensitivity could help control pain in future
Researchers at USC have made mice insensitive to near-freezing temperatures by deactivating select neurons, a development that could one day lead to new treatments for pain in humans. In a study...
View ArticleResearch suggests a new strategy to prevent or halt periodontal disease
By blocking a molecular receptor that bacteria normally target to cause the disease, scientists from the University of Pennsylvania have now demonstrated an ability in a mouse model to both prevent...
View ArticleNew drug could treat Alzheimer's, multiple sclerosis and brain injury
Northwestern has recently been issued patents to cover this new drug class and has licensed the commercial development to a biotech company that has recently completed the first human Phase 1 clinical...
View ArticleScientists Discover Way to 'Turn Off' Sensation of Feeling Cold
'Cold' genes turned off in mice, could lead to development of human drugs Scientists at the University of Southern California have found a way to turn off the neuron responsible for sensing cold in...
View ArticleGatekeeper of brain steroid signals boosts emotional resilience to stress
Glucocorticoids are natural steroids secreted by the body during stress. A small amount of these hormones helps with normal brain function, but their excess is a precipitating factor for...
View ArticleScientists switch off ability to sense cold
Tweet Washington, Feb 13 (IANS) A group of American scientists have successfully managed to selectively shut off in mice the ability to feel cold while leaving the sensation of touch and heat intact....
View ArticleStopping Cold: USC Scientists Turn Off the Ability to Feel Cold (USC -...
(Source: USC - University of Southern California) Stopping Cold: USC Scientists Turn Off the Ability to Feel Cold February 12, 2013 February 12, 2012 -- USC neuroscientists have isolated chills at a...
View ArticleMice's ability to sense cold 'turned off'
Tweet Washington, February 13 (ANI): USC neuroscientists have managed to selectively shut off the ability to sense cold in mice while still leaving them able to sense heat and touch. In prior work,...
View ArticleThe sensation of cold is shut down by inflammation
The sensation of coolness is essential for our everyday life. Although extreme cold causes pain, moderate cooling inhibits pain, such as holding a burned hand under a cold tap. Another way to produce...
View ArticleStopping cold: scientists turn off the ability to feel cold
David McKemy, associate professor of neurobiology in the USC Dornsife College of Letters, Arts and Sciences, and his team managed to selectively shut off the ability to sense cold in mice while still...
View ArticleCool Aid: Drug That Lets Body Temperature Drop Could Save Stroke Victims
During the last decade, a series of studies in The New England Journal of Medicine chronicled the potential benefits of rescuing patients from stroke, heart attack and other conditions by lowering...
View ArticleDrug That Lets Body Temperature Drop Could Save Stroke Victims
By Gary Stix (Click here for the original article) During the last decade, a series of studies in The New England Journal of Medicine chronicled the potential benefits of rescuing patients from...
View ArticleResearchers discover way to block body's response to cold
The research, led by Andrej Romanovsky, MD, PhD, Director of the Systemic Inflammation Laboratory (FeverLab), which is a part of St. Joseph's Trauma Research program, was published in the Feb. 8 issue...
View ArticleHow to block body's response to cold
Washington, Mar 2 (ANI): In a significant finding, researchers have discovered a way to block the body's response to cold using a drug. The research was led by Andrej Romanovsky, MD, PhD, Director of...
View ArticleChronic treatment with Addex Dipraglurant Rescues Impairment of Long-Term...
(Source: Addex Pharmaceuticals Ltd) Geneva, Switzerland, 4 September 2013- Addex Therapeutics (SIX: ADXN), a leading company pioneering allosteric modulation-based drug discovery and development...
View ArticleProtalex Announces PRTX-100 Phase I Data Published in The Journal of...
Highlights pharmacokinetics, safety and pharmacologic activity of PRTX-100 in healthy volunteers SUMMIT, N.J.--(BUSINESS WIRE)--Protalex, Inc. (OTCBB: PRTX), a clinical-stage biopharmaceutical...
View ArticleRegulation of IL-1β–induced NF-κB by hydroxylases links key hypoxic and...
Abstract Hypoxia is a prominent feature of chronically inflamed tissues. Oxygen-sensing hydroxylases control transcriptional adaptation to hypoxia through the regulation of...
View ArticleImplication of the anti-inflammatory bioactive lipid prostaglandin...
Abstract Proinflammatory macrophages are key mediators in several pathologies; thus, controlling their activation is necessary. The endocannabinoid system is implicated in various inflammatory...
View ArticleCombined TRPC3 and TRPC6 blockade by selective small-molecule or genetic...
Abstract Chronic neurohormonal and mechanical stresses are central features of heart disease. Increasing evidence supports a role for the transient receptor potential canonical channels TRPC3 and...
View ArticleBlocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated...
Abstract The immune system plays an instrumental role in obesity and insulin resistance. Here, we unravel the role of the costimulatory molecule CD40 and its signaling intermediates, TNF...
View ArticleIL-1 receptor blockade restores autophagy and reduces inflammation in chronic...
Abstract Patients with chronic granulomatous disease (CGD) have a mutated NADPH complex resulting in defective production of reactive oxygen species; these patients can develop severe colitis and are...
View ArticleResearch Report Confirms Opportunity for Anavex Anti-Cancer and Neuropathic...
(Source: Anavex Life Sciences Corp) View printer-friendly version Research Report Confirms Opportunity for Anavex Anti-Cancer and Neuropathic Pain Compounds Sigma-1 Receptor Modulation Preventing...
View ArticleCholinergic neurotransmission links solitary chemosensory cells to nasal...
Abstract Solitary chemosensory cells (SCCs) of the nasal cavity are specialized epithelial chemosensors that respond to irritants through the canonical taste transduction cascade involving Gα-gustducin...
View ArticleEleven Biotherapeutics Presents Data on Novel Protein Therapeutics for...
CAMBRIDGE, Mass.--(BUSINESS WIRE)--Eleven Biotherapeutics (NASDAQ: EBIO), a clinical-stage biopharmaceutical company discovering and developing protein therapeutics to treat diseases of the eye, today...
View ArticleLifespan boost for mice that feel less pain
No pain, lifespan gain? Mice lacking a type of pain receptor live significantly longer than other mice and have a more youthful metabolism. The finding hints at new targets for efforts to improve...
View ArticleProteins causing daytime sleepiness may be tied to bone formation, osteoporosis
Proteins causing daytime sleepiness are tied to bone formation, a target for osteoporosis, says new research, "Orexin Regulates Bone Remodeling via a Dominant Positive Central Action and a Subordinate...
View ArticleCSHL Scientists Use Cancer Drugs to Reverse Alzheimer's-Like Memory Loss in 2...
EGFR inhibitors used to fight cancer show surprising efficacy in fly, mouse models of beta amyloid-associated memory loss. Cold Spring Harbor, NY (PRWEB) September 24, 2012 A team of neuroscientists...
View ArticleHow ghrelin primes your brain for PTSD (Video)
Ghrelin, a stress-induced hormone, primes the brain for post traumatic stress disorder (PTSD), says an October 15, 2013 news release by Anne Trafton, MIT News Office, "Ghrelin, a stress-induced...
View ArticleBlocking protein expression delays onset of multiple sclerosis in mice, study...
Exactly why this happens is still unclear. It may be, in part, that blocking expression of the protein, SIRT1, enhances the production of cells that make the insulating myelin sheath necessary for the...
View ArticleExperimental Drug Eases Autistic Behaviors in Mice
(HealthDay News) -- An experimental drug reduced two signature characteristics of autism -- repetitive behavior and abnormal social interactions -- in laboratory mice, new research finds. The drug,...
View ArticleTRPV4-mediated mechanotransduction regulates the metabolic response of...
Abstract Mechanical loading of joints plays a critical role in maintaining the health and function of articular cartilage. The mechanism(s) of chondrocyte mechanotransduction are not fully understood,...
View ArticleVEGF-C blockade with OPT-302 reduces established wet AMD lesions in the mouse...
(Source: Circadian Technologies Limited) ASX and Media release 6 May 2014 VEGF-C blockade with OPT-302 reduces established wet AMD lesions in the mouse Data presented at the Association for Research...
View ArticleBGU Researchers now understand more about how the Protein AAT works after...
(Source: Ben-Gurion University of the Negev) 05/01/2014 תוכן BGU researcher Dr. Eli Lewis and his team have discovered one of the mechanisms behind the promising treatment of Type 1 Diabetes with...
View ArticleHow metabolism and brain activity are linked (McGill University)
(Source: McGill University) Study sheds light on why diet may help control seizures in epilepsy patients A new study by scientists at McGill University and the University of Zurich shows a direct link...
View ArticleHow caffeine intake may help cut Alzheimer's risk
Tweet Washington, October 10 (ANI): Caffeine consumption has been linked to a reduced risk of Alzheimer's disease in recent studies. Now, a new University of Illinois study has shed light on how this...
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